Chrome is based on the existing Webkit rendering, which mostly adheres to web standards, and is also used in similar form by the Safari browser. So your first best bet is to work within the official standards of HTML (or XHTML) and CSS. Beyond that you should do some testing as not all things will display the same in every browser.

One other thing you can do with Chrome is to utilize the features of the Google Gears component it ships with. For instance, this lets you create a persistent client-side database which you can query using JavaScript. (Note that this won’t automatically make the data available on all computers the user may visit your site with; you need to handle synchronization for that and rely on all browsers on the different computers having Gears installed.)

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